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'SeisImager Pickwin V3.02 With Plotrefa V2.68 By SHOCK' 2022



 


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Category:MacOS file managers Category:2011 software Category:Free application software Category:Utilities for macOS than in the controls. The number of genes that are shared between both CLL and AML is low in comparison with the number of genes that are shared between AML and solid tumors ([@b27]). We could observe this trend in our study as well. We have found 73 and 48 genes that are shared between CLL and AML in our study, but only 4 and 7 genes, respectively, that are shared between AML and solid tumors. The fact that genes shared between CLL and AML are not associated with the involvement of non-hematopoietic tissues is in accordance with the results from [@b27]. [@b8] have used an algorithm (GRAIL) to analyze the data of [@b27]. The GRAIL algorithm first defines, from each dataset, a reference gene set for which (i) each probe set has a (discriminatory) expression signature and (ii) the gene sets are maximally discriminative. Afterwards, the two studies are compared with respect to genes shared between their CLL and AML or solid tumor gene lists. [@b8] found a significantly higher overlap between CLL and AML than between CLL and solid tumors. The comparison of our two datasets with GRAIL revealed many genes that are shared by the CLL and AML but not by the CLL and solid tumors. These results agree with those reported by [@b8] and are not in contradiction with their observations. Thus, our findings together with the results from [@b8] and [@b27] support the idea that CLL and AML are closely related and they share many genes that are involved in similar processes and pathways. The shared genes are not associated with the involvement of non-hematopoietic tissues. We thank Ruth O'Brien for editorial assistance and members of the Bioinformatics group at Karolinska Institutet for discussions and support. Funding to pay the Open Access publication charges for this article was provided by the Karolinska Institute. Figures and Tables ================== ![The non-hematopoietic fraction of the leukemic cells. **(a)** Immunophenotypic analysis of the leukemic cells reveals that they are of B-cell origin. The expression

 

 

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'SeisImager Pickwin V3.02 With Plotrefa V2.68 By SHOCK' 2022
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